Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 20th World Conference on Pharmaceutical Chemistry and Drug Design Amsterdam, Netherlands.

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Scientific Program Day 1
Scientific Program Day 2

Day 2 :

  • Drug Designing, Pharmaceutical Organic Chemistry Drug Target Discovery
Location: Conference Hall 1
Speaker

Chair

Heyam Saad

Dubai Pharmacy College for Girls, UAE

Session Introduction

Rakesh S. Shivatare

JJT University India

Title: Inventing formula for drug development and analytical techniques is the key for pharmaceutical industries
Speaker
Biography:

Rakesh S. Shivatare has completed his Master in pharmacy (Pharmacognosy) at the age of 24 years from Pune University. He had worked as research officer and having 5 year experience in formulation analytical method development. He has published more than 15 papers in reputed national and international journals.            

Abstract:

The pharmaceutical industry is essentially defined by innovation. Research on the forefront of science, the creation of new knowledge bases, the invention of new medicines, and the improvement of existing drugs constitute the fuel that propels the firms in this industry.

Formulation can be categorized according to the route of administration. Pharmaceutical development information provides the scientific rationale for formulation development and justification for a suitable dosage form. Excipients are the major fraction of the solid dosage forms which serve as diluents to allow the formulation of appropriately sized tablets and coatings to protect the tablet from undesirable organoleptic qualities of the drug substance. Solid state reactions in the dosage form can occur when the drug substance is reactive and may be accelerated by physical and chemical interaction with excipients.

In the field of pharmaceutical research, the analytical investigation of bulk drug materials, intermediates, drug products, drug formulations, impurities and degradation products, and biological samples containing the drugs and their metabolites is very important. From the commencement of official pharmaceutical analysis, analytical assay methods were included in the compendial monographs with the aim to characterize the quality of bulk drug materials by setting limits of their active ingredient content. In recent years, the assay methods in the monographs include titrimetry, spectrometry, chromatography, and capillary electrophoresis; also the electro analytical methods can be seen in the literature.

Gokalp Iscan

Anadolu University, Turkey

Title: Antimicrobial and antioxidant activities of secondary metabolites of endophytic fungi isolated from origanum onites

Time : 11:20-11:50

Speaker
Biography:

Gokalp Iscan is a pharmacognosist at Anadolu University, Turkey. He is associate professor in Department of Pharmacognosy, Faculty of Pharmacy. Dr Iscan has been in his current position as lecturer and researcher since December 1999. He has his expertise in microbial transformations of aroma chemicals, bioactive metabolites, essential oils, natural products and bioactivity assays. He has published more than 35 research papers in refereed International journals. Dr Iscan worked in fifteen national and international research projects.
 

 

Abstract:

Entophytic fungi live as a symbiotic organisms in higher plants tissues and may improve the host resistance to biotic and abiotic stresses. Endophytes have a very rich biodiversity and they can synthesize so many bioactive secondary metabolites. These natural compounds are challenging potential resources for the pharmaceutical industry. In the present study three endophytic fungi were isolated and subcultured from the leaves of Origanum onites (oregano) and identified by molecular methods. The fungi (Alternaria brassicicola, A. alternata and A. tenuissima) were cultured in liquid media for 14 days and extracted. Crude extracts were analysed with Liquid chromatography/mass spectrometry (LC/MS) system. Furthermore, extracts were evaluated for their antimicrobial and antioxidant effects. Alternaria brassicicola and A. alternata extracts showed significant growth inhibition against selected pathogenes between the concentration range of 7 to 125 µg/mL.
 

Yavuz Bülent Köse

Anadolu University, Turkey

Title: Essential oil composition and antimicrobial activity of salvia cryptantha montbret & aucher ex benth
Speaker
Biography:

Köse received his M.sc degree in 2001 from Osmangazi University Graduate School of Science. He received his Ph. D. from the Anadolu University Anadolu University Graduate School of Science with. Now He is Prof. Dr. of Anadolu University Faculty of Pharmacy, Pharmaceutical Botany Department. He has published about 30 academic papers in reputed journals. 

Abstract:

Salvia L. is the largest genus of Lamiaceae and is composed of nearly 1000 species and widely distributed in five regions of the world: Central and South America, Western Asia, Eastern Asia, Africa, Europe. Turkey is one of the centers of diversity for Salvia. With the new described species, Turkey is now home to 100 Salvia species, 53 (53%) of which are endemic. Many species of Salvia are native to Mediterranean Europe and have been traditionally used for the treatment of a range of problems including; digestive and circulation disturbances, bronchitis, coughs, asthma, memory problems, angina, mouth and throat inflammation, depression and excessive sweating. In the present study, plant materials were collected from Turkey, NiÄŸde, Meydan Platau at July 2015. Hydrodistilled essential oil of S. cryptantha were analysed by Gas Chromatography-Mass Spectrometry and FID coupled GC systems. The essential oil was tested for its antimicrobial activity against ten bacteria species and eight different pathogenic Candida strains, by using CLSI M7-A7 and M27-A2 protocols respectively. According to GC/ MS results, 1,8-cineole (30.2%) and β-pinene (10.9%) were found as major constituents of the essential oil. Essential oil of the S. cryptantha showed weak antimicrobial effects (250 to >2000 µg/mL, MIC ) when compared to standard agents.
 

Bülent Ergun

Anadolu University, Turkey

Title: In vitro selectivity of anethol combination with standard antifungals against candida sp.
Speaker
Biography:

Bulent Ergun received his MSc degree in 1986 from Ankara University Graduate School of Science. He received his PhD from Anadolu University Graduate School of Science. He has conducted Post-doctoral research at the University of Munich. At present, he is working as Head of Toxicology Department, Anadolu University Faculty of Pharmacy.
 

Abstract:

Anethol is a crystalline volatile and aromatic methoxybenzene substituted by a prop-1-en-1-yl group at para-position, a characteristic consituent of most Apiaceae and mainly anise (Pimpinella anisum L.), described as hazardous toxic, allerjen compound in some safety regulations. Oxiconazole and terbinafine are active pharmaceutical igredients used in oral and topical antifungal therapy protocols with toxicological potential. In this present study anticandidal combinations of anethol and standard drugs oxiconazole and terbinafine were evaluated in vitro by checkerboard combinations using the Biomek4000 pipetting robot against human pathogenic standard and clinical Candida albicans, C. glabrata , C.tropicalis.  C. parapsilosis, C. krusei strains. To evaluate the synergic concentration and selectivity, in vitro Allivibrio fischeri bioluminescent assay as well as human fibroblast cell XTT-WS1 assays were conducted. According to the fractional inhibitory concentration (FIC) calculations anethol+terbinafine combinations resulted indifferent, however, the anethol+oxiconazole combination showed synergism and additive activity at 0.28-0.53 µg/mL FIC, respectively. The synergistic concentrations showed relative high toxicity in the in vitro assays. Further detailed work is ongoing to evaluate the selectivity of anethol isomers.
 

Hadyah Al-otaibi

Pharmacist, Saudi Arabia

Title: Design of taste masked enteric orodispersible tablets of diclofenac sodium by applying fluid bed coating technology
Biography:

She aspires to cultivate my skills and knowledge to contribute in drug development and formulation of new combinations, which would serve my country and the world.aspire to cultivate my skills and knowledge to contribute in drug development and formulation of new combinations, which would serve my country and the world. She done her Bachelors Degree in Pharmaceutical Sciences from King Saud University in Riyadh, KSA. And her Master's Degree in Pharmaceutical Science from King Saud University in Riyadh, KSA.

Abstract:

Diclofenac sodium (DS) is a non-steroidal anti-inflammatory drug that has a bitter taste with local irritation to stomach. The aim of this research is to formulate taste masked DS orally dispersible tablets (ODTs) with drug release in the intestine. Pellets of DS were designed using sugar sphere cores layered with DS followed by enteric coat of Eudragit L100 and then a second coat of Eudragit E100 for taste masking. The produced pellets had high loading efficiency of 99.52 % with diameters ranged from 493.7 to 638.9 μm. Pellets were spherical with smooth surfaces as examined by SEM. Pellets with 12 % enteric coated Eudragit L100 followed by 5% Eudragit E 100 showed 1.4±0.5% DS release in simulated gastric fluid (SGF) while completely dissoluted in simulated intestinal fluid (SIF). The pellets were used for formulation of ODTs. In vitro disintegration times of ODTs ranged between 20±0.26 and 46±0.27 sec in simulated saliva fluid (SSF). While, dissolution was less than 10% in SGF and all drug was released in SIF. The release rate was higher for the promising formulation (F12) in SIF compared with the marketed product voltaren® 25 mg. The optimized ODTs formulation had smoothness with highly acceptable taste.