20^th World Conference on Pharmaceutical Chemistry and Drug Design December 10-11, 2018 Amsterdam, Netherlands

Köse received his M.sc degree in 2001 from Osmangazi University Graduate School of Science. He received his Ph. D. from the Anadolu University Anadolu University Graduate School of Science with. Now He is Prof. Dr. of Anadolu University Faculty of Pharmacy, Pharmaceutical Botany Department. He has published about 30 academic papers in reputed journals.

Salvia L. is the largest genus of Lamiaceae and is composed of nearly 1000 species and widely distributed in five regions of the world: Central and South America, Western Asia, Eastern Asia, Africa, Europe. Turkey is one of the centers of diversity for Salvia. With the new described species, Turkey is now home to 100 Salvia species, 53 (53%) of which are endemic. Many species of Salvia are native to Mediterranean Europe and have been traditionally used for the treatment of a range of problems including; digestive and circulation disturbances, bronchitis, coughs, asthma, memory problems, angina, mouth and throat inflammation, depression and excessive sweating. In the present study, plant materials were collected from Turkey, Niğde, Meydan Platau at July 2015. Hydrodistilled essential oil of S. cryptantha were analysed by Gas Chromatography-Mass Spectrometry and FID coupled GC systems. The essential oil was tested for its antimicrobial activity against ten bacteria species and eight different pathogenic Candida strains, by using CLSI M7-A7 and M27-A2 protocols respectively. According to GC/ MS results, 1,8-cineole (30.2%) and β-pinene (10.9%) were found as major constituents of the essential oil. Essential oil of the S. cryptantha showed weak antimicrobial effects (250 to >2000 µg/mL, MIC ) when compared to standard agents.

Bulent Ergun received his MSc degree in 1986 from Ankara University Graduate School of Science. He received his PhD from Anadolu University Graduate School of Science. He has conducted Post-doctoral research at the University of Munich. At present, he is working as Head of Toxicology Department, Anadolu University Faculty of Pharmacy.

Anethol is a crystalline volatile and aromatic methoxybenzene substituted by a prop-1-en-1-yl group at para-position, a characteristic consituent of most Apiaceae and mainly anise (Pimpinella anisum L.), described as hazardous toxic, allerjen compound in some safety regulations. Oxiconazole and terbinafine are active pharmaceutical igredients used in oral and topical antifungal therapy protocols with toxicological potential. In this present study anticandidal combinations of anethol and standard drugs oxiconazole and terbinafine were evaluated in vitro by checkerboard combinations using the Biomek4000 pipetting robot against human pathogenic standard and clinical Candida albicans, C. glabrata , C.tropicalis. C. parapsilosis, C. krusei strains. To evaluate the synergic concentration and selectivity, in vitro Allivibrio fischeri bioluminescent assay as well as human fibroblast cell XTT-WS1 assays were conducted. According to the fractional inhibitory concentration (FIC) calculations anethol+terbinafine combinations resulted indifferent, however, the anethol+oxiconazole combination showed synergism and additive activity at 0.28-0.53 µg/mL FIC, respectively. The synergistic concentrations showed relative high toxicity in the in vitro assays. Further detailed work is ongoing to evaluate the selectivity of anethol isomers.

She aspires to cultivate my skills and knowledge to contribute in drug development and formulation of new combinations, which would serve my country and the world. She done her Bachelor's Degree in Pharmaceutical Sciences from King Saud University in Riyadh, KSA. And done her Master's Degree in Pharmaceutical Science from King Saud University in Riyadh, KSA.

Diclofenac sodium (DS) is a non-steroidal anti-inflammatory drug that has a bitter taste with local irritation to stomach. The aim of this research is to formulate taste masked DS orally dispersible tablets (ODTs) with drug release in the intestine. Pellets of DS were designed using sugar sphere cores layered with DS followed by enteric coat of Eudragit L100 and then a second coat of Eudragit E100 for taste masking. The produced pellets had high loading efficiency of 99.52 % with diameters ranged from 493.7 to 638.9 μm. Pellets were spherical with smooth surfaces as examined by SEM. Pellets with 12 % enteric coated Eudragit L100 followed by 5% Eudragit E 100 showed 1.4±0.5% DS release in simulated gastric fluid (SGF) while completely dissoluted in simulated intestinal fluid (SIF). The pellets were used for formulation of ODTs. In vitro disintegration times of ODTs ranged between 20±0.26 and 46±0.27 sec in simulated saliva fluid (SSF). While, dissolution was less than 10% in SGF and all drug was released in SIF. The release rate was higher for the promising formulation (F12) in SIF compared with the marketed product voltaren® 25 mg. The optimized ODTs formulation had smoothness with highly acceptable taste.

Tannaz dehpouri Place of birth: mazandaran sari iran Father’s name: gholamreza dehpouri Permanent adress: iran mazandaran sari farhang street 4818814847 Present adress: mazandaran university of medical sciences emam khomeini hospital Email: tannaz_dehpoori@yahoo.com

Introduction: Medications are the backbone of therapy in healthcare system, however adverse drug reactions (ADRs) are unpreventable, and drug safety surveillance is a key solution to prevent fatal events in hospitals. The aim of this study was to present ADRs encountered in a referral hospital in North of Iran. Methods: This study was conducted at Imam Khomeini hospital, a teaching hospital affiliated to Mazandaran University of Medical sciences, Sari, Iran. ADRs reported by Healthcare professionals including nurses, pharmacists, general physicians, specialists and the other therapeutic staff were evaluated. Frequency of ADRs, suspected medications, the final outcome of ADRs was evaluated in the study. Results: A total of 109 yellow cards were completed during 2016-2017-2018, most of the reports were generated by nurses (61 cases, 56%) followed by pharmacists (42 cases, 39%). Twenty four drugs were identified to cause adverse events. Rash and skin eruption was the most ADR reported (59 cases, 54%). Discussion: The most adverse drug reactions were reported by Vancomycin injection (20cases, 18% ) followed by Ciprofloxacin (12 cases, 11%) and Metronidazole (7 cases, 6%). 88 cases (81%) completely recovered after experiencing ADRs and in one case the reaction leaded to the mortality (Anaphylactic reaction following Vancomycin). In fifty eight cases, the suspected drug was discontinued. Conclusion: Cutaneous reactions were the most prevalent event experienced by patients and vancomycin was the most associated drug. Nursing staff had the highest participation rate among health care professionals in ADR reporting.

Tareq Abu Izneid is working as professor at Umm Al Qura University in Saudi Arabia.

DC-SIGN is a C-type lectin expressed on dendritic cells. It contains four Ca2+- dependent carbohydrate recognition domains that specifically recognize complex mannose glycans present on the surface of invading microorganisms. For some pathogens, including viruses like HIV, Ebola or Dengue [1], this recognition event contributes to infection transmission, making DC-SIGN a very interesting target for the design of antiviral agents. Dengue virus infection (DENV) is currently expanding worldwide since it is present in more than 128 countries in the world[2]. DENV is the most prevalent mosquitoborne viral disease causing clinical syndromes in humans. As there is no available vaccine or treatment, DENV infection has become a major international public health concern and the search for anti-dengue treatment is of extreme importance and it is an active field of research. Among the DC-SIGN antagonists reported in the literature, two mannose derivatives have drawn ourattention (Ligand I[3] and Ligand II[4]), which are two of the most potent monovalent mannose derived DCSIGN antagonists that are reported so far. The well-known weak binding affinity which characterizes carbohydrate-protein interactions, can be overcome by multivalent presentation. Based on the previous experience of our group, herein we discuss the synthesis of the two ligands I and II functionalized with an azido linker and their conjugation to a rod-core system[5] in order to prepare both hexa- and di-valent glycodendrimers as DC-SIGN antagonists.