Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 20th World Conference on Pharmaceutical Chemistry and Drug Design Amsterdam, Netherlands.

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Scientific Program Day 1
Scientific Program Day 2

Day 1 :

  • Pharmaceutical Formulations | Formulation R&D | Clinical Research vs Clinical Trails | Bioavailability Studies and Assessment | Contract Research Organizations | Recent approaches to Biosimilars
Location: Conference Hall 1
Speaker

Chair

Heyam Saad

Dubai Pharmacy College for Girls, UAE

Session Introduction

Tannaz Dehpouri

Emam Khomeini Hospital, Iran

Title: The output of a hospital-based phamacovigilance system in a referral center in north of Iran
Speaker
Biography:

Tannaz Dehpouri; Pharm D, Pharmaceutical Care Department, Emam Khomeini Hospital, Faculty of Medical Sciences, Iran
 

Abstract:

Introduction: Medications are the backbone of therapy in healthcare system, however adverse drug reactions (ADRs) are unpreventable, and drug safety surveillance is a key solution to prevent fatal events in hospitals. The aim of this study was to present ADRs encountered in a referral hospital in North of Iran. Methods: This study was conducted at Imam Khomeini hospital, a teaching hospital affiliated to Mazandaran University of Medical sciences, Sari, Iran. ADRs reported by Healthcare professionals including nurses, pharmacists, general physicians, specialists and the other therapeutic staff were evaluated. Frequency of ADRs, suspected medications, the final outcome of ADRs was evaluated in the study. Results: A total of 109 yellow cards were completed during 2016-2017-2018, most of the reports were generated by nurses (61 cases, 56%) followed by pharmacists (42 cases, 39%). Twenty four drugs were identified to cause adverse events. Rash and skin eruption was the most ADR reported (59 cases, 54%). Discussion: The most adverse drug reactions were reported by Vancomycin injection (20cases, 18% ) followed by Ciprofloxacin (12 cases, 11%) and Metronidazole (7 cases, 6%). 88 cases (81%) completely recovered after experiencing ADRs and in one case the reaction leaded to the mortality (Anaphylactic reaction following Vancomycin). In fifty eight cases, the suspected drug was discontinued. Conclusion: Cutaneous reactions were the most prevalent event experienced by patients and vancomycin was the most associated drug. Nursing staff had the highest participation rate among health care professionals in ADR reporting.
 

Mahmoud Balbaa

Alexandria University, Egypt

Title: Modification of the insulin signalling by Nigella sativa oil and antidiabetic drugs in streptozotocin-induced diabetic rats
Speaker
Biography:

Mahmoud Balbaa has pursued his PhD from Hokkaido University, Japan during the period of 1984-1988. Currently, he is working as a Professor of Biochemistry at Alexandria University, Egypt. He was appointed as the Head of the Biochemistry Department, Alexandria University, Egypt from 2007 to 2009. His research has included the study of enzyme characterization and inhibition, cell signaling and the biochemical parameters in diseases. Based on this research and fellowship training, he has received several awards and honors, such as Post-doctoral Fellowship from the Medical Research Council, Canada and another Post-doctoral Fellowship from AIEJ, Japan. He is serving as an Editorial Member of several reputed journals. He has authored more than 50 research articles.
 

Abstract:

Nigella sativa (NS) is black seed with different biological activities and its anti-diabetic effect is one of the highly investigated activities. Streptozotocin-induced diabetic rats (fed with a high-fat diet) were treated daily with NS Oil (NSO) in order to study its anti-liver or brain insulin resistance. In the hepatic tissues, the administration of NSO significantly induced the gene expression of insulin receptor compared to NSO-untreated rats. In addition, it up-regulated the expression of insulin-like growth factor 1 and phosphoinositide-3 kinase. On the other hand, the expression of ADAM-17 was down-regulated, whereas the level of TIMP-3 confirmed its down-regulation. In the brain, it corrected the reduced insulin signaling pathway (p-IRS/ p-AKT/p-GSK-3β) resulted from the stimulation of GSK-3β level. This, in turn, contributed to a decreased Tau phosphorylation along with changes in the protein phosphatase PP2A level. In conclusion, NSO or its combined treatments with anti-diabetic drugs have a possible protective and modifying effect of the insulin resistance through enhancing the hepatic and brain insulin signaling pathway.
 

Heyam Saad

Dubai Pharmacy College for Girls, UAE

Title: The impact of surface funtionalization in design of targatted drug delivery system
Speaker
Biography:

Heyam Saad, M. Pharm., and Ph-D. She is working as a head of pharmaceutics department in Dubai Pharmacy College, UAE. Prof. contributed more than 70 articles to reputed international scientific journals and conferences, in different conventional, controlled and targeted drug delivery systems in pharmaceutical product development. She has been invited as speaker to numerous International conferences .Reviewer and member of editorial board of many international journals.

Abstract:

Surface functionalization represents the key design of an efficient and successful targeted nanocarrier-based drug delivery system for cancer therapy. The main aim of developing such delivery system is to overcome the limitations of the current conventional chemotherapeutic products. Despite some improvement they offer, there are major problems summarized in non-selectivity and specificity, off-target side effects, multidrug resistance [MDR], low response rate and lack of efficiency.  Versatile strategies and approaches have been addressed by researchers and academicians. Active and passive targeting strategies are the main types of targeting strategies along with dual, stimuli responsive and multifunctional or theranostic liposomal nanoparticles. The initial and complex challenging task is the selection of the appropriate targeting moiety to interact with specific receptor overexpressed on tumor cell. However, the variable microenvironment pathophysiology within tumor cell and other biological interactions in the body are obstacles stands out in achieving the aforementioned goal.  Of the cancerous cells. This presentation will highlight the these challenges, approaches for targeting strategies in design of an efficient targeted drug delivery system in cancer. Theranostics is a combination of digostics and therapeutics in one single platform. It has a potential role in management of cancer and other diseases. Nanomedicine is a medical application of Nanotechnology based products involving both nanomaterials and nanodevices. Both can establish the pillar to  treat,  diagnose, detect, and management of the disease.
 

Nagla Gamil

Dubai Pharmacy College for Girls, UAE

Title: Natural Hepatoprotective Drugs
Speaker
Biography:

Naglaa Gamil is a professor of  Pharmaceutical Chemistry and Natural Products Department and Chief Academic Officer at Dubai Pharmacy College. And an Associate Professor, Faculty of Pharmacy at  Cairo University, Egypt. Her field of Specialization is major Field of Specialization, Pharmacognosy-Phytochemistry

Abstract:

Liver diseases are considered as one of the serious health problems, as it is an important organ for the detoxification and deposition of endogenous and exogenous substances. A number of pharmacological and chemical agents act as hepatotoxins and produce a variety of liver ailments. Steroids, vaccines and antiviral drugs which have been employed as a therapy for liver diseases, have potential adverse effects especially when administered for long terms. Traditional healing practices are now wide spread amongst about 80% of the developed countries population and often termed alternative or complementary medicine.

Aim: In the absence of reliable liver-protective drugs in modern medicine, hepatoprotective drugs from plant sources seem to have attractive alternatives. The aim of this scientific lecture is designed to focus in the medicinal plants as well as the other alternative medicines which can be used as hepatoprotective and antihepatotoxic agent.

Medicinal plants that are found in the Arabic Gulf, India and United State of America with scientific researches were discussed.  The active constituents, mechanism of actions, safety, side effects and the contraindication of each plant were discussed as well. Other alternative medicines like aromatherapy, acupuncture therapy, breathing therapy and relaxation therapy were deliberated.

Rakesh S. Shivatare

JJT University India

Title: Novel drug delivery systems : new lifeline for herbal drugs
Speaker
Biography:

Rakesh S. Shivatare has completed his Master in pharmacy (Pharmacognosy) at the age of 24 years from Pune University. He had worked as research officer and having 5 year experience in formulation analytical method development. He has published more than 15 papers in reputed national and international journals.

Abstract:

Novel drug delivery systems (NDDS) are designed to achieve a continuous delivery of drugs at predictable and reproducible kinetics over an extended period of time in the circulation. The potential advantages of this concept include minimisation of drug related side effects due to controlled therapeutic blood levels instead of oscillating blood levels, improved patient compliance due to reduced frequency of dosing and the reduction of the total dose of drug administered.

In the past few decades, considerable attention has been focused on the development of novel drug delivery system for herbal drugs. The novel carriers should ideally fulfill two prerequisites. Firstly, it should deliver the drug at a rate directed by the needs of the body, over the period of treatment. Secondly, it should channel the active entity of herbal drug to the site of action. Conventional dosage forms including prolonged-release dosage forms are unable to meet none of these. In phyto-formulation research, developing nano dosage forms (polymeric nanoparticles and nanocapsules, liposomes, solid lipid nanoparticles, phytosomes and nanoemulsion etc.) have a number of advantages for herbal drugs, including enhancement of solubility and bioavailability, protection from toxicity, enhancement of pharmacological activity, enhancement of stability, improving tissue macrophages distribution, sustained delivery, protection from physical and chemical degradation etc.

Thus the nano-sized novel drug delivery systems of herbal drugs have a potential future for enhancing the activity and overcoming problems associated with plant medicines.

Fazilatun Nessa

Dubai Pharmacy College for Girls, UAE

Title: Trace heavy metal contents of herbal products available in UAE pharmaceutical markets
Speaker
Biography:

Fazilatun Nessa, Ph.D. is working as an Associate Professor in the Department of Pharmaceutical Chemistry and Natural Products of Dubai Pharmacy College for Girls, Dubai, UAE. She has completed her Ph.D. studies in Pharmaceutical Chemistry from Universiti Sains Malaysia, Penang, Malaysia. She has presented her several researches at International Conferences and published a number of research articles in peer reviewed international journals. Her research area comprised of isolation, characterization of bioactive compounds from natural sources, bioactivity evaluation of extracts/isolates, analytical method development/validation and quality-control studies of pharmaceutical/herbal products.

Abstract:

About 80% of world population use herbal products in one time of their lifetime therefore, research become more oriented and focused on the evaluation of safety and quality control of commercially marketed herbal products. In advanced researches it has been documented that plants contain not only beneficial minerals, secondary metabolites but also contain non-essential minerals, toxic elements as they are contaminated with environmental pollutants specially heavy metals. Thirty one over the counter herbal products that are available within the UAE pharmaceutical markets were investigated for the presence of seven heavy metals; Cd, Pb, Fe, As, Ni, Al and Hg and to determine whether or not they pose a risk of heavy metal toxicity in regards to World Health Organization (WHO) levels. Sample solution was prepared by a dry ashing or wet digestion procedure. All metals were analyzed either by Graphite Furnace or Flame Atomic Absorption Spectrometry. Method validation was performed by evaluating metal recovery studies and within-day precision studies. The studied samples of herbal products exhibited positive response for all heavy metals except Hg. The results were compared with established WHO permissible limits as for Provisional Tolerable Daily Intake for Pb is 0.02 to 3μg/kg BW (body weight), for Fe is 0.8mg/kg BW and for Ni is 12μg/kg BW; Weekly Intake for Hg is 1μg/kg BW, for Al is 1mg/kg BW and for As is 15μg/kg BW; and Monthly Intake for Cd is 25μg/kg BW respectively. In conclusion, the herbal products available within UAE contained tolerable levels of toxic heavy metals except Al and Fe for some products.

Jana Janockova

University Hospital Hradec Kralove, Czech Republic

Title: Prediction of BBB permeability using PAMPA assay
Biography:

Jana Janockova has pursued her PhD in 2015 from the Department of Biochemistry, P J Safarik University in Kosice (Slovakia). Currently, as a Postdoctoral Fellow at the Biomedical Research Center (BRC), University Hospital Hradec Kralove (Czech Republic) is responsible for in vitro testing and identification of biochemical and pharmacological properties and cytotoxicity evaluation of newly synthetized potential therapeutics for Alzheimer´s disease, Narcolepsy or as antidotes in organophosphate intoxication.
 

Abstract:

One of the successes for CNS drugs is to penetrate the Blood-Brain Barrier (BBB) and achieve the therapeutic targets. Therefore, the rapid screening for potential BBB-penetration of drug candidates provides important information in early drug discovery research. The Parallel Artificial Membrane Permeability Assay (PAMPA) is a high-throughput screening tool applied to predict the passive transport of potential drugs across BBB. It is the non-cell-based in vitro assay often used in pharmaceutical industry which is carried out in a coated 96-well membrane filter. An artificial lipid membrane represented by the polar brain lipid is applied on a hydrophobic filter and the compounds are screened according to their pass from a Donor (D) compartment through the filter to an Acceptor (A) part. Subsequently, A and D wells are analyzed by LC/MS or in UV-Vis spectrophotometer. The assessed concentrations are then used for calculation of the permeability coefficient (Pe). Compounds with Pe lower than 2.0×10-6 cm.s-1 were classified as potentially non-BBB permeable (CNS-) and compounds with Pe higher than 4.0×10-6 cm.s-1 were recognized as potentially BBB permeable (CNS+). Of course, the assay can predict the CNS bioavailability based on the passive diffusion and active transport as well as efflux mechanisms are not considered. In the study, we correlated PAMPA-obtained permeability of some drugs (e.g. donepezil, rivastigmine, tacrine, testosterone, furosemide, sulfasalazine) and the results were compared with the real values mentioned in the literature.