Pharmaceutical Chemistry and Drug Design

Salvia L. is the largest genus of Lamiaceae and is composed of nearly 1000 species and widely distributed in five regions of the world: Central and South America, Western Asia, Eastern Asia, Africa, Europe. Turkey is one of the centers of diversity for Salvia. With the new described species, Turkey is now home to 100 Salvia species, 53 (53%) of which are endemic. Many species of Salvia are native to Mediterranean Europe and have been traditionally used for the treatment of a range of problems including; digestive and circulation disturbances, bronchitis, coughs, asthma, memory problems, angina, mouth and throat inflammation, depression and excessive sweating. In the present study, plant materials were collected from Turkey, NiÄŸde, Meydan Platau at July 2015. Hydrodistilled essential oil of S. cryptantha were analysed by Gas Chromatography-Mass Spectrometry and FID coupled GC systems. The essential oil was tested for its antimicrobial activity against ten bacteria species and eight different pathogenic Candida strains, by using CLSI M7-A7 and M27-A2 protocols respectively. According to GC/ MS results, 1,8-cineole (30.2%) and β-pinene (10.9%) were found as major constituents of the essential oil. Essential oil of the S. cryptantha showed weak antimicrobial effects (250 to >2000 µg/mL, MIC ) when compared to standard agents.