Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 20th World Conference on Pharmaceutical Chemistry and Drug Design Amsterdam, Netherlands.

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Scientific Program Day 1
Scientific Program Day 2

Day 1 :

  • Pharmaceutical Formulations | Formulation R&D | Clinical Research vs Clinical Trails | Bioavailability Studies and Assessment | Contract Research Organizations | Recent approaches to Biosimilars
Location: Conference Hall 1
Speaker

Chair

Heyam Saad

Dubai Pharmacy College for Girls, UAE

Session Introduction

Tannaz Dehpouri

Emam Khomeini Hospital, Iran

Title: The output of a hospital-based phamacovigilance system in a referral center in north of Iran
Speaker
Biography:

Tannaz Dehpouri; Pharm D, Pharmaceutical Care Department, Emam Khomeini Hospital, Faculty of Medical Sciences, Iran
 

Abstract:

Introduction: Medications are the backbone of therapy in healthcare system, however adverse drug reactions (ADRs) are unpreventable, and drug safety surveillance is a key solution to prevent fatal events in hospitals. The aim of this study was to present ADRs encountered in a referral hospital in North of Iran. Methods: This study was conducted at Imam Khomeini hospital, a teaching hospital affiliated to Mazandaran University of Medical sciences, Sari, Iran. ADRs reported by Healthcare professionals including nurses, pharmacists, general physicians, specialists and the other therapeutic staff were evaluated. Frequency of ADRs, suspected medications, the final outcome of ADRs was evaluated in the study. Results: A total of 109 yellow cards were completed during 2016-2017-2018, most of the reports were generated by nurses (61 cases, 56%) followed by pharmacists (42 cases, 39%). Twenty four drugs were identified to cause adverse events. Rash and skin eruption was the most ADR reported (59 cases, 54%). Discussion: The most adverse drug reactions were reported by Vancomycin injection (20cases, 18% ) followed by Ciprofloxacin (12 cases, 11%) and Metronidazole (7 cases, 6%). 88 cases (81%) completely recovered after experiencing ADRs and in one case the reaction leaded to the mortality (Anaphylactic reaction following Vancomycin). In fifty eight cases, the suspected drug was discontinued. Conclusion: Cutaneous reactions were the most prevalent event experienced by patients and vancomycin was the most associated drug. Nursing staff had the highest participation rate among health care professionals in ADR reporting.
 

Mahmoud Balbaa

Alexandria University, Egypt

Title: Modification of the insulin signalling by Nigella sativa oil and antidiabetic drugs in streptozotocin-induced diabetic rats
Speaker
Biography:

Mahmoud Balbaa has pursued his PhD from Hokkaido University, Japan during the period of 1984-1988. Currently, he is working as a Professor of Biochemistry at Alexandria University, Egypt. He was appointed as the Head of the Biochemistry Department, Alexandria University, Egypt from 2007 to 2009. His research has included the study of enzyme characterization and inhibition, cell signaling and the biochemical parameters in diseases. Based on this research and fellowship training, he has received several awards and honors, such as Post-doctoral Fellowship from the Medical Research Council, Canada and another Post-doctoral Fellowship from AIEJ, Japan. He is serving as an Editorial Member of several reputed journals. He has authored more than 50 research articles.
 

Abstract:

Nigella sativa (NS) is black seed with different biological activities and its anti-diabetic effect is one of the highly investigated activities. Streptozotocin-induced diabetic rats (fed with a high-fat diet) were treated daily with NS Oil (NSO) in order to study its anti-liver or brain insulin resistance. In the hepatic tissues, the administration of NSO significantly induced the gene expression of insulin receptor compared to NSO-untreated rats. In addition, it up-regulated the expression of insulin-like growth factor 1 and phosphoinositide-3 kinase. On the other hand, the expression of ADAM-17 was down-regulated, whereas the level of TIMP-3 confirmed its down-regulation. In the brain, it corrected the reduced insulin signaling pathway (p-IRS/ p-AKT/p-GSK-3β) resulted from the stimulation of GSK-3β level. This, in turn, contributed to a decreased Tau phosphorylation along with changes in the protein phosphatase PP2A level. In conclusion, NSO or its combined treatments with anti-diabetic drugs have a possible protective and modifying effect of the insulin resistance through enhancing the hepatic and brain insulin signaling pathway.
 

Heyam Saad

Dubai Pharmacy College for Girls, UAE

Title: The impact of surface funtionalization in design of targatted drug delivery system
Speaker
Biography:

Heyam Saad, M. Pharm., and Ph-D. She is working as a head of pharmaceutics department in Dubai Pharmacy College, UAE. Prof. contributed more than 70 articles to reputed international scientific journals and conferences, in different conventional, controlled and targeted drug delivery systems in pharmaceutical product development. She has been invited as speaker to numerous International conferences .Reviewer and member of editorial board of many international journals.

Abstract:

Surface functionalization represents the key design of an efficient and successful targeted nanocarrier-based drug delivery system for cancer therapy. The main aim of developing such delivery system is to overcome the limitations of the current conventional chemotherapeutic products. Despite some improvement they offer, there are major problems summarized in non-selectivity and specificity, off-target side effects, multidrug resistance [MDR], low response rate and lack of efficiency.  Versatile strategies and approaches have been addressed by researchers and academicians. Active and passive targeting strategies are the main types of targeting strategies along with dual, stimuli responsive and multifunctional or theranostic liposomal nanoparticles. The initial and complex challenging task is the selection of the appropriate targeting moiety to interact with specific receptor overexpressed on tumor cell. However, the variable microenvironment pathophysiology within tumor cell and other biological interactions in the body are obstacles stands out in achieving the aforementioned goal.  Of the cancerous cells. This presentation will highlight the these challenges, approaches for targeting strategies in design of an efficient targeted drug delivery system in cancer. Theranostics is a combination of digostics and therapeutics in one single platform. It has a potential role in management of cancer and other diseases. Nanomedicine is a medical application of Nanotechnology based products involving both nanomaterials and nanodevices. Both can establish the pillar to  treat,  diagnose, detect, and management of the disease.
 

Nagla Gamil

Dubai Pharmacy College for Girls, UAE

Title: Natural Hepatoprotective Drugs
Speaker
Biography:

Naglaa Gamil is a professor of  Pharmaceutical Chemistry and Natural Products Department and Chief Academic Officer at Dubai Pharmacy College. And an Associate Professor, Faculty of Pharmacy at  Cairo University, Egypt. Her field of Specialization is major Field of Specialization, Pharmacognosy-Phytochemistry

Abstract:

Liver diseases are considered as one of the serious health problems, as it is an important organ for the detoxification and deposition of endogenous and exogenous substances. A number of pharmacological and chemical agents act as hepatotoxins and produce a variety of liver ailments. Steroids, vaccines and antiviral drugs which have been employed as a therapy for liver diseases, have potential adverse effects especially when administered for long terms. Traditional healing practices are now wide spread amongst about 80% of the developed countries population and often termed alternative or complementary medicine.

Aim: In the absence of reliable liver-protective drugs in modern medicine, hepatoprotective drugs from plant sources seem to have attractive alternatives. The aim of this scientific lecture is designed to focus in the medicinal plants as well as the other alternative medicines which can be used as hepatoprotective and antihepatotoxic agent.

Medicinal plants that are found in the Arabic Gulf, India and United State of America with scientific researches were discussed.  The active constituents, mechanism of actions, safety, side effects and the contraindication of each plant were discussed as well. Other alternative medicines like aromatherapy, acupuncture therapy, breathing therapy and relaxation therapy were deliberated.

Rakesh S. Shivatare

JJT University India

Title: Novel drug delivery systems : new lifeline for herbal drugs
Speaker
Biography:

Rakesh S. Shivatare has completed his Master in pharmacy (Pharmacognosy) at the age of 24 years from Pune University. He had worked as research officer and having 5 year experience in formulation analytical method development. He has published more than 15 papers in reputed national and international journals.

Abstract:

Novel drug delivery systems (NDDS) are designed to achieve a continuous delivery of drugs at predictable and reproducible kinetics over an extended period of time in the circulation. The potential advantages of this concept include minimisation of drug related side effects due to controlled therapeutic blood levels instead of oscillating blood levels, improved patient compliance due to reduced frequency of dosing and the reduction of the total dose of drug administered.

In the past few decades, considerable attention has been focused on the development of novel drug delivery system for herbal drugs. The novel carriers should ideally fulfill two prerequisites. Firstly, it should deliver the drug at a rate directed by the needs of the body, over the period of treatment. Secondly, it should channel the active entity of herbal drug to the site of action. Conventional dosage forms including prolonged-release dosage forms are unable to meet none of these. In phyto-formulation research, developing nano dosage forms (polymeric nanoparticles and nanocapsules, liposomes, solid lipid nanoparticles, phytosomes and nanoemulsion etc.) have a number of advantages for herbal drugs, including enhancement of solubility and bioavailability, protection from toxicity, enhancement of pharmacological activity, enhancement of stability, improving tissue macrophages distribution, sustained delivery, protection from physical and chemical degradation etc.

Thus the nano-sized novel drug delivery systems of herbal drugs have a potential future for enhancing the activity and overcoming problems associated with plant medicines.

Fazilatun Nessa

Dubai Pharmacy College for Girls, UAE

Title: Trace heavy metal contents of herbal products available in UAE pharmaceutical markets
Speaker
Biography:

Fazilatun Nessa, Ph.D. is working as an Associate Professor in the Department of Pharmaceutical Chemistry and Natural Products of Dubai Pharmacy College for Girls, Dubai, UAE. She has completed her Ph.D. studies in Pharmaceutical Chemistry from Universiti Sains Malaysia, Penang, Malaysia. She has presented her several researches at International Conferences and published a number of research articles in peer reviewed international journals. Her research area comprised of isolation, characterization of bioactive compounds from natural sources, bioactivity evaluation of extracts/isolates, analytical method development/validation and quality-control studies of pharmaceutical/herbal products.

Abstract:

About 80% of world population use herbal products in one time of their lifetime therefore, research become more oriented and focused on the evaluation of safety and quality control of commercially marketed herbal products. In advanced researches it has been documented that plants contain not only beneficial minerals, secondary metabolites but also contain non-essential minerals, toxic elements as they are contaminated with environmental pollutants specially heavy metals. Thirty one over the counter herbal products that are available within the UAE pharmaceutical markets were investigated for the presence of seven heavy metals; Cd, Pb, Fe, As, Ni, Al and Hg and to determine whether or not they pose a risk of heavy metal toxicity in regards to World Health Organization (WHO) levels. Sample solution was prepared by a dry ashing or wet digestion procedure. All metals were analyzed either by Graphite Furnace or Flame Atomic Absorption Spectrometry. Method validation was performed by evaluating metal recovery studies and within-day precision studies. The studied samples of herbal products exhibited positive response for all heavy metals except Hg. The results were compared with established WHO permissible limits as for Provisional Tolerable Daily Intake for Pb is 0.02 to 3μg/kg BW (body weight), for Fe is 0.8mg/kg BW and for Ni is 12μg/kg BW; Weekly Intake for Hg is 1μg/kg BW, for Al is 1mg/kg BW and for As is 15μg/kg BW; and Monthly Intake for Cd is 25μg/kg BW respectively. In conclusion, the herbal products available within UAE contained tolerable levels of toxic heavy metals except Al and Fe for some products.

Jana Janockova

University Hospital Hradec Kralove, Czech Republic

Title: Prediction of BBB permeability using PAMPA assay
Biography:

Jana Janockova has pursued her PhD in 2015 from the Department of Biochemistry, P J Safarik University in Kosice (Slovakia). Currently, as a Postdoctoral Fellow at the Biomedical Research Center (BRC), University Hospital Hradec Kralove (Czech Republic) is responsible for in vitro testing and identification of biochemical and pharmacological properties and cytotoxicity evaluation of newly synthetized potential therapeutics for Alzheimer´s disease, Narcolepsy or as antidotes in organophosphate intoxication.
 

Abstract:

One of the successes for CNS drugs is to penetrate the Blood-Brain Barrier (BBB) and achieve the therapeutic targets. Therefore, the rapid screening for potential BBB-penetration of drug candidates provides important information in early drug discovery research. The Parallel Artificial Membrane Permeability Assay (PAMPA) is a high-throughput screening tool applied to predict the passive transport of potential drugs across BBB. It is the non-cell-based in vitro assay often used in pharmaceutical industry which is carried out in a coated 96-well membrane filter. An artificial lipid membrane represented by the polar brain lipid is applied on a hydrophobic filter and the compounds are screened according to their pass from a Donor (D) compartment through the filter to an Acceptor (A) part. Subsequently, A and D wells are analyzed by LC/MS or in UV-Vis spectrophotometer. The assessed concentrations are then used for calculation of the permeability coefficient (Pe). Compounds with Pe lower than 2.0×10-6 cm.s-1 were classified as potentially non-BBB permeable (CNS-) and compounds with Pe higher than 4.0×10-6 cm.s-1 were recognized as potentially BBB permeable (CNS+). Of course, the assay can predict the CNS bioavailability based on the passive diffusion and active transport as well as efflux mechanisms are not considered. In the study, we correlated PAMPA-obtained permeability of some drugs (e.g. donepezil, rivastigmine, tacrine, testosterone, furosemide, sulfasalazine) and the results were compared with the real values mentioned in the literature.
 

  • Drug Designing, Pharmaceutical Organic Chemistry Drug Target Discovery
Location: Conference Hall 1
Speaker

Chair

Heyam Saad

Dubai Pharmacy College for Girls, UAE

Session Introduction

Rakesh S. Shivatare

JJT University India

Title: Inventing formula for drug development and analytical techniques is the key for pharmaceutical industries
Speaker
Biography:

Rakesh S. Shivatare has completed his Master in pharmacy (Pharmacognosy) at the age of 24 years from Pune University. He had worked as research officer and having 5 year experience in formulation analytical method development. He has published more than 15 papers in reputed national and international journals.            

Abstract:

The pharmaceutical industry is essentially defined by innovation. Research on the forefront of science, the creation of new knowledge bases, the invention of new medicines, and the improvement of existing drugs constitute the fuel that propels the firms in this industry.

Formulation can be categorized according to the route of administration. Pharmaceutical development information provides the scientific rationale for formulation development and justification for a suitable dosage form. Excipients are the major fraction of the solid dosage forms which serve as diluents to allow the formulation of appropriately sized tablets and coatings to protect the tablet from undesirable organoleptic qualities of the drug substance. Solid state reactions in the dosage form can occur when the drug substance is reactive and may be accelerated by physical and chemical interaction with excipients.

In the field of pharmaceutical research, the analytical investigation of bulk drug materials, intermediates, drug products, drug formulations, impurities and degradation products, and biological samples containing the drugs and their metabolites is very important. From the commencement of official pharmaceutical analysis, analytical assay methods were included in the compendial monographs with the aim to characterize the quality of bulk drug materials by setting limits of their active ingredient content. In recent years, the assay methods in the monographs include titrimetry, spectrometry, chromatography, and capillary electrophoresis; also the electro analytical methods can be seen in the literature.

Gokalp Iscan

Anadolu University, Turkey

Title: Antimicrobial and antioxidant activities of secondary metabolites of endophytic fungi isolated from origanum onites

Time : 11:20-11:50

Speaker
Biography:

Gokalp Iscan is a pharmacognosist at Anadolu University, Turkey. He is associate professor in Department of Pharmacognosy, Faculty of Pharmacy. Dr Iscan has been in his current position as lecturer and researcher since December 1999. He has his expertise in microbial transformations of aroma chemicals, bioactive metabolites, essential oils, natural products and bioactivity assays. He has published more than 35 research papers in refereed International journals. Dr Iscan worked in fifteen national and international research projects.
 

 

Abstract:

Entophytic fungi live as a symbiotic organisms in higher plants tissues and may improve the host resistance to biotic and abiotic stresses. Endophytes have a very rich biodiversity and they can synthesize so many bioactive secondary metabolites. These natural compounds are challenging potential resources for the pharmaceutical industry. In the present study three endophytic fungi were isolated and subcultured from the leaves of Origanum onites (oregano) and identified by molecular methods. The fungi (Alternaria brassicicola, A. alternata and A. tenuissima) were cultured in liquid media for 14 days and extracted. Crude extracts were analysed with Liquid chromatography/mass spectrometry (LC/MS) system. Furthermore, extracts were evaluated for their antimicrobial and antioxidant effects. Alternaria brassicicola and A. alternata extracts showed significant growth inhibition against selected pathogenes between the concentration range of 7 to 125 µg/mL.
 

Yavuz Bülent Köse

Anadolu University, Turkey

Title: Essential oil composition and antimicrobial activity of salvia cryptantha montbret & aucher ex benth
Speaker
Biography:

Köse received his M.sc degree in 2001 from Osmangazi University Graduate School of Science. He received his Ph. D. from the Anadolu University Anadolu University Graduate School of Science with. Now He is Prof. Dr. of Anadolu University Faculty of Pharmacy, Pharmaceutical Botany Department. He has published about 30 academic papers in reputed journals. 

Abstract:

Salvia L. is the largest genus of Lamiaceae and is composed of nearly 1000 species and widely distributed in five regions of the world: Central and South America, Western Asia, Eastern Asia, Africa, Europe. Turkey is one of the centers of diversity for Salvia. With the new described species, Turkey is now home to 100 Salvia species, 53 (53%) of which are endemic. Many species of Salvia are native to Mediterranean Europe and have been traditionally used for the treatment of a range of problems including; digestive and circulation disturbances, bronchitis, coughs, asthma, memory problems, angina, mouth and throat inflammation, depression and excessive sweating. In the present study, plant materials were collected from Turkey, NiÄŸde, Meydan Platau at July 2015. Hydrodistilled essential oil of S. cryptantha were analysed by Gas Chromatography-Mass Spectrometry and FID coupled GC systems. The essential oil was tested for its antimicrobial activity against ten bacteria species and eight different pathogenic Candida strains, by using CLSI M7-A7 and M27-A2 protocols respectively. According to GC/ MS results, 1,8-cineole (30.2%) and β-pinene (10.9%) were found as major constituents of the essential oil. Essential oil of the S. cryptantha showed weak antimicrobial effects (250 to >2000 µg/mL, MIC ) when compared to standard agents.
 

Bülent Ergun

Anadolu University, Turkey

Title: In vitro selectivity of anethol combination with standard antifungals against candida sp.
Speaker
Biography:

Bulent Ergun received his MSc degree in 1986 from Ankara University Graduate School of Science. He received his PhD from Anadolu University Graduate School of Science. He has conducted Post-doctoral research at the University of Munich. At present, he is working as Head of Toxicology Department, Anadolu University Faculty of Pharmacy.
 

Abstract:

Anethol is a crystalline volatile and aromatic methoxybenzene substituted by a prop-1-en-1-yl group at para-position, a characteristic consituent of most Apiaceae and mainly anise (Pimpinella anisum L.), described as hazardous toxic, allerjen compound in some safety regulations. Oxiconazole and terbinafine are active pharmaceutical igredients used in oral and topical antifungal therapy protocols with toxicological potential. In this present study anticandidal combinations of anethol and standard drugs oxiconazole and terbinafine were evaluated in vitro by checkerboard combinations using the Biomek4000 pipetting robot against human pathogenic standard and clinical Candida albicans, C. glabrata , C.tropicalis.  C. parapsilosis, C. krusei strains. To evaluate the synergic concentration and selectivity, in vitro Allivibrio fischeri bioluminescent assay as well as human fibroblast cell XTT-WS1 assays were conducted. According to the fractional inhibitory concentration (FIC) calculations anethol+terbinafine combinations resulted indifferent, however, the anethol+oxiconazole combination showed synergism and additive activity at 0.28-0.53 µg/mL FIC, respectively. The synergistic concentrations showed relative high toxicity in the in vitro assays. Further detailed work is ongoing to evaluate the selectivity of anethol isomers.
 

Hadyah Al-otaibi

Pharmacist, Saudi Arabia

Title: Design of taste masked enteric orodispersible tablets of diclofenac sodium by applying fluid bed coating technology
Biography:

She aspires to cultivate my skills and knowledge to contribute in drug development and formulation of new combinations, which would serve my country and the world.aspire to cultivate my skills and knowledge to contribute in drug development and formulation of new combinations, which would serve my country and the world. She done her Bachelors Degree in Pharmaceutical Sciences from King Saud University in Riyadh, KSA. And her Master's Degree in Pharmaceutical Science from King Saud University in Riyadh, KSA.

Abstract:

Diclofenac sodium (DS) is a non-steroidal anti-inflammatory drug that has a bitter taste with local irritation to stomach. The aim of this research is to formulate taste masked DS orally dispersible tablets (ODTs) with drug release in the intestine. Pellets of DS were designed using sugar sphere cores layered with DS followed by enteric coat of Eudragit L100 and then a second coat of Eudragit E100 for taste masking. The produced pellets had high loading efficiency of 99.52 % with diameters ranged from 493.7 to 638.9 μm. Pellets were spherical with smooth surfaces as examined by SEM. Pellets with 12 % enteric coated Eudragit L100 followed by 5% Eudragit E 100 showed 1.4±0.5% DS release in simulated gastric fluid (SGF) while completely dissoluted in simulated intestinal fluid (SIF). The pellets were used for formulation of ODTs. In vitro disintegration times of ODTs ranged between 20±0.26 and 46±0.27 sec in simulated saliva fluid (SSF). While, dissolution was less than 10% in SGF and all drug was released in SIF. The release rate was higher for the promising formulation (F12) in SIF compared with the marketed product voltaren® 25 mg. The optimized ODTs formulation had smoothness with highly acceptable taste.